Stem cells have the capacity both to self‐renew and to give rise to differentiated progeny, and are vital to the organization of multicellular organisms. Stem cells raise a number of fundamental questions regarding lineage restriction and cellular differentiation, and they hold enormous promise for cell‐based therapies. Here I propose a theoretical framework for stem cell biology based on the concepts of autopoiesis (self‐production) and complementarity. I argue that stem cells are pivotal in the self‐production of the organism and that we (...) need complementary approaches to understand their probabilistic behavior. I discuss how this framework generates testable hypotheses regarding stem‐cell functions. BioEssays 26:1013‐1016, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Transposable elements (TEs) are sequences currently or historically mobile, and are present across all eukaryotic genomes. A growing interest in understanding the regulation and function of TEs has revealed seemingly dichotomous roles for these elements in evolution, development, and disease. On the one hand, many gene regulatory networks owe their organization to the spread of cis‐elements and DNA binding sites through TE mobilization during evolution. On the other hand, the uncontrolled activity of transposons can generate mutations and contribute to disease, (...) including cancer, while their increased expression may also trigger immune pathways that result in inflammation or senescence. Interestingly, TEs have recently been found to have novel essential functions during mammalian development. Here, the function and regulation of TEs are discussed, with a focus on LINE1 in mammals. It is proposed that LINE1 is a beneficial endogenous dual regulator of gene expression and genomic diversity during mammalian development, and that both of these functions may be detrimental if deregulated in disease contexts. (shrink)

Analisa as relações teóricas e empíricas entre os termos “Competência em Informação” e “Inclusão Digital”; “Competência Informacional” e “Inclusão Digital”; “Competência Crítica em Informação” e “Inclusão Digital”. De natureza básica, bibliográfica, documental, descritiva e análise de conteúdo. Para tanto, utiliza-se o método quali-quantitativo. Como resultado, afirma-se que, o principal desafio da CoInfo na conjuntura atual estar centrado nos processos de exclusão digital sistêmica em escala global, à medida que não há Sociedade da Informação sem consciência cidadã, bem como justiça epistêmica (...) na era digital. Portanto, afirmar-se que, a aquisição de CoInfo vai de encontro a apropriação oportunista dialética dos políticos, que, usam a inclusão digital como algo feito e acabado simplesmente pela doação e instalação de kits de computadores e acesso à internet no Brasil, nos últimos 23 anos de implantação da sociedade da informação. (shrink)

Ex 5,22-6.1 presents Moses appealing to the Lord and God's answer to the prophet. Moses' prayer is configured as a cry of despair stemming from a bewilderment of his vocation as a promoter of liberty, subdued by human conditions. The prophet of failure is paradoxical, since it reveals both as a personal and divine failure. For these reasons, Moses has faith put to the test. His reaction shown by a fiery prayer and full of fervor. God responds with the renewal (...) of the promise of liberation. (shrink)

A análise literária do Sl 117, a menor unidade do saltério hebraico, revela um conteúdo teológico-espiritual de caráter messiânico de relevância e atualidade para o cristianismo e o judaísmo. O estudo do texto hebraico em sua forma final – sem excluir, contudo, informações de índole diacrônica – apresenta sob a forma típica da poética hebraica elementos que ressaltam as características do louvor a Deus. O salmo propõe uma relação espiritual “carinhosa” no louvor para com o Deus de Israel; fornece explicitamente (...) as motivações deste elogio que se fundamenta na anamnese da misericórdia divina para com o homem; assim como na recordação da fidelidade à aliança de Javé com o Antigo Israel. (shrink)

This article presents the recent literature about the church Nossa Senhora da Consolação, considered through the prism of the study of sacred art. After a historical overview about the neighborhood and the ancient temple of Consolation, will be highlighted some most relevant artistic aspects of architecture and works of art gathered in the sacred building, designed by German engineer Maximilian Emil Hehl, whose inspiration reports to the formal and stylistic features of Romanesque architecture as well as the influences of eclecticism (...) with a predominance of Romanesque Revival architecture and Gothic Revival in São Paulo in the early twentieth century. (shrink)

A presente pesquisa pretende apresentar, analisar e questionar a prática jurídica dos núcleos de prática jurídica da PUC Minas, tendo presente as normas emanadas do Ministério da Educação e a Missão da PUC Minas, conforme o ensino da Igreja no que concerne às universidades católicas. Palavras-chave: Igreja; Cidadania; Assistência jurídica; Acesso à justiça. ABSTRACT This research aims at presenting, analysing and questioning juridical practice in the nuclei of juridical practice of PUC Minas, considering the norms issued by the Ministry of (...) Education as well as the mission of PUC Minas, according to the teaching of the church in what concerns Catholic institutions of higher education. Key words: Church; Citizenship; Juridical assistance; Access to justice. (shrink)

Abordagens (etno)filosóficas no e do direito -- Criminologia, direito penal e direito internacional humanitário -- Educação em direitos humanos e fundamentais -- Hermanêutica jurídica e sistemas teóricos do conhecimento no direito -- Gênero na transversalidade no direito : epistemologias da marginalização do 'outro' não hegemônico.

O objetivo deste trabalho é apresentar a filosofia de Kant e o pensamento de Bohr como formas de conhecimento que se encontram, segundo alguns comentadores, a partir de conceitos da física clássica. Ademais, a epistemologia de Kant apresentou grande aproximação com a filosofia natural de Newton e, conceitualmente, alguns limites de fronteira com a filosofia da física quântica, se consideramos a fase inicial da mecânica clássica. Tais conceitos limítrofes adquiriram forma na física de Bohr e, por sua vez, se modificaram (...) no pensamento do físico dinamarquês. Assim, aborda-se aqui a posição de Bohr sobre conceitos aproximados da filosofia kantiana, pelo viés clássico da preservação de conceitos como espaço, tempo, realismo e causalidade da física. Por outro lado, serão apresentados argumentos que indicam como não se sustentam todas as interpretações que construíram um “Bohr kantiano”. (shrink)

ABSTRACT This article aims to analyze, from a Bakhtinian perspective, the grotesque construction of Mexican artist Frida Kahlo’s body through a religious worldview. Therefore, we analyze two of her self-portraits, taking into account the dialogic relations constructed between the grotesque representations and Catholic symbology. The analyzed utterances, in which the specificities of the creative competence of the author-creator in her aesthetic activity are inferred, showed that a dialogue is established between the painting El venado herido and Catholic Saint Sebastian and (...) between the painting Las dos fridas and the image of the Sacred Heart of Jesus. (shrink)

Resumo: O presente artigo tem por objetivo tentar elucidar as relações entre a tradição contratualista moderna e a noção nietzschiana de "Estado" que está presente na obra Genealogia da moral. Para realizar essa tarefa, iniciaremos pelo exame do argumento de Nietzsche acerca do aparecimento do "Estado", apresentado nas seções 16 e 17 da segunda dissertação do livro citado. Num segundo momento, trazemos um breve resumo dos argumentos de três contratualistas clássicos, a saber, Hobbes, Rousseau e Locke. Essas duas primeiras partes (...) do nosso trabalho servirão como premissas a partir das quais iremos promover a confrontação entre Nietzsche e os contratualistas. Esse procedimento nos dará oportunidade para apresentarmos uma problemática secundária, qual seja, a questão da "sociedade" das "bestas louras" pensada à luz da noção contratualista de pacto. (shrink)

This article presents the recent literature about Cathedral of See considered from the History of Arts perspective in São Paulo. After highlight some functional, stylistic and historical data about the building idealized by Brazilian Archbishop Dom Duarte Leopoldo e Silva and designed by German engineer Maximilian Emil Hehl , will be highlighted the most important artistic aspects of architecture and Works of Art gathered in the paulist sacred buildings. The article also highlights the Cathedral in its connection with the history (...) of the city and the Archdiocese of São Paulo. (shrink)

Objetivou-se estratificar fatores de risco para doenças cardiovasculares (DCV) em dez anos em jogadores de basquetebol em cadeiras de rodas. O percentual de risco cardiovascular foi estratificado pelos escores de Framingham (ERF) e de Risco Global (ERG). Dos treze jogadores avaliados, 38,46% apresentava sobrepeso e obesidade e 77%, alterações na porcentagem de gordura corporal e na circunferência abdominal. O ERF identificou 15,38% dos jogadores com risco intermediário para desenvolvimento de DCV e pelo ERG, 15,4% dos homens apresentava risco intermediário, 7,7% (...) alto risco por diabetes e 7,7% muito alto risco por doenças ateroscleróticas. Os resultados de composição corporal demonstram uma predisposição para desenvolvimento de DCV, sendo que o ERG identificou indivíduos com alto risco e muito alto risco. Conclui-se que a identificação dos fatores de risco é útil para que ocorra uma maior prevenção das DCV e aconselhamento adequado sobre adoção de hábitos de vida saudáveis por esses indivíduos. (shrink)

Tem como objetivo refletir acerca do preconceito e da discriminação no âmbito das práticas colaborativas de representação de conteúdos por meio da Folksonomia. A pesquisa possui caráter qualitativo e a hermenêutica enquanto método, aliado à interdisciplinaridade de campos e de teorias. Quando não considerados no âmbito da Folksonomia, o preconceito e a discriminação emergem como uma gap epistêmica, uma vez que ambos podem se apropriar da Folksonomia para prosperar. Destaca que a Folksonomia não pressupõe a imposição de regras para a (...) seleção de tags a serem utilizadas pelos(as) usuários(as) em ambiente web, haja vista o seu caráter colaborativo. Por isso ela pode ser utilizada através da lógica do preconceito e discriminação, aplicada por humanos e/ou robôs (autônomos ou assistidos) para a rápida popularização de fake news e da cultura do cancelamento- algumas das estruturas perversas que promovem a vertigem da Sociedade da Informação, e que têm refletido sobre os sujeitos LGBTQIA+. (shrink)

Este artigo aborda de maneira preliminar a efetivação das políticas públicas educacionais no Assentamento Roça do Povo, no município de Itabuna-BA, analisando a legislação vigente, pontuando direitos conquistados pelas populações rurais e principalmente pelos campesinos por meio das suas lutas e reivindicações. Também foram analisadas as dificuldades, desafios, progressos, formação de professores e a importância da educação no campo para os campesinos. Desta forma, abordamos a importância de conhecer e estudar as leis que regulamentam a Educação do Campo, pois, a (...) prática educacional deve ser condizente com a realidade cotidiana, buscando valorizar a identidade e a cultura do campesinato. Além disso, este estudo visa ainda valorizar e defender a importância da educação no campo. Por fim, a presente pesquisa busca difundir as informações coletadas no Assentamento Roça do Povo, objetivando provocar inquietação na sociedade e aos órgãos públicos, para que possam olhar com maior atenção para a Educação do Campo e compreender a importância dela para os campesinos no Brasil, em especial na Bahia. (shrink)

This paper deals with the questions of emergence and complex (mental and social) systems and with downward determination from the viewpoint of perspectival realism. These are issues concerning the foundations of the human sciences, generally speaking, and particularly psychology and sociology. A criterion is put forward, which distinguish metaphysicalfrom ontological (conceptual) problems, and the notions of complex, hierarchic system and causation that would be suitable for those that defend emergence and perspectivist foundations of the human sciences are discussed. Este artigo (...) trata das questões da emergência de sistemas complexos (mentais e sociais) e da determinação descendente do ponto de vista do realismo perspectivista. Essas são questões sobre os fundamentos das ciências humanas em geral e, em particular, da psicologia e da sociologia. É proposto um critério para distinguir problemas metafísicos de problemas ontológicos (ou conceituais), e são discutidas as noções de sistema complexo hierárquico e de causação que seriam adequadas para uma fundamentação emergentista e perspectivista das ciências humanas. (shrink)

A 27 de Outubro comemora a Igreja os santos Vicente, Sabina e Cristeta. Conhecidos como os Mártires de Évora, a eles foi erguida no século XV na cidade alentejana, no local onde se dizia terem nascido, uma ermida, ampliada no século seguinte já à conta do Município, que ainda hoje mantém a propriedade. Era-lhes também dedicada, na nave direita da Sé de Évora, uma das capelas laterais desaparecidas após a intervenção da Direcção-geral dos Monumentos Nacionais na década de 40 (...) do século XX.A naturalidade dos santos irmãos, embora assumida pelos eborenses, sobretudo após as argumentações de André de Resende, mantém-se de difícil comprovação, sendo por muitos autores atribuída não à cidade alentejana, mas a Talavera de la Reina (Toledo). Martirizados no século IV na cidade espanhola de Ávila, São Vicente e suas irmãs aí foram sepultados e em sua honra construída uma grande basílica, expressão do reconhecimento e devoção aos chamados Santos de Ávila. Da descrição legendária das suas vidas e martírios decorre a respectiva iconografia. Tudo aconteceu em tempo do governador Daciano, enviado à Península Ibérica pelo imperador Diocleciano, que promoveu uma intensa perseguição aos cristãos. O jovem Vicente, que poderia servir de incentivo aos pagãos pelo seu comportamento cristão exemplar, foi chamado à presença de Daciano que o pretendeu convencer a sacrificar a Júpiter. Perante a recusa, mandou conduzi-lo a uma das praças da cidade e obrigá-lo a executar o sacrifício ou a ser morto. Colocado sobre o altar de pedra, esta tornou-se mole ficando impressas as suas pegadas, prodígio que deixou todos os presentes admirados e convencidos de que o Deus de Vicente era o verdadeiro. Tal facto levou Daciano a suspender temporariamente a condenação, tendo mandado o jovem para a prisão, onde foi visitado por suas irmãs Sabina e Cristeta. Convencido por elas a fugir, foram os três perseguidos e apanhados em Ávila, sendo sujeitos a vários suplícios e finalmente partidas as suas cabeças com paus e pedras. Os seus corpos foram deixados ao abandono para pasto dos animais; todavia apareceu uma enorme serpente que os protegia e que se enroscou à volta de um judeu rico da cidade que pretendia desprezar os santos despojos e que só se viu livre da serpente quando prometeu converter-se ao cristianismo. Os mártires acabaram por ser sepultados pelos cristãos, espalhando-se rapidamente a sua devoção.O repertório iconográfico, muito reduzido no que concerne a arquidiocese de Évora, confina--se praticamente à igreja de São Vicente, onde se encontra a pedra na qual supostamente terá deixado as marcas dos seus pés; alguns painéis do retábulo-mor representam “São Vicente conduzido perante o altar de Júpiter”, “São Vicente na prisão e a visita de suas irmãs”, “o martírio de São Vicente”, e “o judeu impedido pela serpente de ultrajar os corpos dos três santos”. A representação escultórica segue muito de perto a de Ávila. Todos trazem a palma do martírio, São Vicente um livro aberto ou semicerrado. As irmãs Sabina e Cristeta apresentam uma iconografia pouco definida, sendo por vezes necessário, quando não estão inseridas no contexto duma cena conhecida, que o nome lhes seja sotoposto para fácil identificação. (shrink)

Emérita Quito was the first woman from the Philippines to complete a Ph.D. in Philosophy. Her early Scholastic training as an undergraduate was at the University of Santo Tomas expanded to include phenomenology and existentialism during her graduate studies at major European universities. Upon returning home she began to focus on the idea of developing a methodology for investigating indigenous Filipino philosophy. How does one reveal the concepts and principles underlying the belief systems within a country that has suffered a (...) thousand years of occupation by foreign forces, that speaks with hundreds of different dialects across more than seven thousand islands spread across more than one hundred thousand square miles? This amazing philosopher published extensively not only in western philosophy, but on that indigenous to this island nation, prior to the incursions of western nations and the introduction to the Philippines of western philosophical views. (shrink)

Fábio Alves dos Santos (1954-2013) cursou Pedagogia, Ciências Sociais e Teologia, era Especialista em Filosofia da Religião (PUC Minas), Advogado (PUC Minas) e Mestre em Direito Constitucional (UFMG). Lecionou na PUC Minas como professor de Cultura Religiosa e depois como professor no Curso de Direito, atuando principalmente no Serviço de Assistência Judiciária – SAJ, especialmente cuidado de causas populares como as da ASMARE (Associação dos Catadores de Papel, Papelão e Material Reaproveitável de Belo Horizonte), da Pastoral de Rua, da (...) Pastoral Carcerária, de movimentos de “Sem Casa”, de ocupações e tantos outros grupos. Fábio sofria de grave problema de visão há mais de 15 anos. Quase ficou cego depois de diversas cirurgias de miopia. Isso, porém, não o impedia de seguir seu constante compromisso com as lutas populares. Na última entrevista que concedeu, menos de um mês antes de sua morte (19 de outubro de 2013), depois de duro sofrimento de quase dois anos, no tratamento de um câncer no pâncreas, conta um pouco de sua vida, sua luta e sua percepção de várias realidades, especialmente da Igreja e da pastoral. Militante formado na Teologia da Libertação, de profunda espiritualidade, marcada por traços da religiosidade popular nordestina e comprometida com a libertação, Fábio Alves também buscou em sua vida abrir-se à teologia do pluralismo religioso, especialmente com o Santo Daime, em cuja tradição religiosa chegou a ser “fardado”, mantendo uma profunda atitude espiritual aberta ao diálogo inter-religioso. Sua primeira publicação foi “Começo de mundo novo: sofrimento, luta e vitória dos posseiros de Santana dos Frades”, Sergipe, numa versão popular em 1981 e outra pela Editora Vozes (1990). Fruto de sua dissertação de mestrado, publicou o livro “Direito Agrário: política fundiária no Brasil (1995). Em 2001 saiu seu último livro, uma coletânea de artigos publicados em diversos jornais: “Em defesa da vida”. Num artigo em Horizonte (2004), juntamente com o advogado, amigo e colega Prof. Cristiano de Melo Bastos, discutiu “A prática jurídica na missão da PUC Minas”. Palavras-chave : Teologia da Libertação. Militância. Igreja Católica. Pastoral. Lutas populares. (shrink)

Ellen Furlong and Laurie Santos helpfully summarize a number of fascinating studies of certain influences on both human and monkey behavior. As someone who works primarily in philosophy, I am not in a position to dispute the details of the studies themselves. But in this brief commentary I do want to raise some questions about the inferences Furlong and Santos make on the basis of those studies. In general, I worry that they may be overreaching beyond what (...) their own data suggests. (shrink)

Neste artigo abordo a questão da interpretação de Hegel acerca do conceito de apercepção pura transcendental em Kant. Como procuro mostrar, Hegel inicialmente faz uma análise positiva do argumento kantiano acerca da apercepção, concordando com Kant sobre a unidade e o caráter pensante e autorreferente do eu. Com efeito, para Hegel, Kant elabora uma compreensão muito importante sobre a natureza do conhecimento, ao afirmar que a unidade conceitual da autoconsciência constitui a unidade do objeto. Contudo, por outro lado, Hegel analisa (...) o argumento kantiano sob outra perspectiva, sustentando que Kant não desenvolve coerentemente a tese da unidade da apercepção pura e acaba por considerar a autoconsciência apenas do ponto de vista subjetivo, em uma relação externa com o objeto. Neste contexto, minha leitura é que Hegel incorpora em sua Lógica aquilo que ele concebe como um elemento especulativo no interior do argumento kantiano sobre a apercepção pura transcendental, transformando, assim, a compreensão kantiana sobre o eu penso em sua concepção lógico-especulativa sobre o conceito subjetivo. Nestes termos, dialogo com a interpretação de Robert Pippin em Hegel ́s Idealism, discordando da afirmação do autor, segundo a qual, a concepção hegeliana sobre o conceito na Ciência da Lógica consiste em uma continuidade da concepção kantiana sobre a apercepção pura transcendental. (shrink)

The therapeutic misconception has been seen as presenting an ethical problem because failure to distinguish the aims of research participation from those receiving ordinary treatment may seriously undermine the informed consent of research subjects. Hence, most theoretical and empirical work on the problems of the therapeutic misconception has been directed to evaluate whether, and to what degree, this confusion invalidates the consent of subjects. We argue here that this focus on the understanding component of informed consent, while important, might be (...) too narrow to capture the ethical complexity of the therapeutic misconception. We show that concerns about misplaced trust and exploitation of such trust are also relevant, and ought to be taken into account, when considering why the therapeutic misconception matters ethically. (shrink)

The aim of this study was to explore how Belgian nurses view issues related to the development, dissemination and implementation of a code of ethics for nurses. Fifty nurses took part in eight focus groups. The participants stated that, on the whole, a code of ethics for nurses would be useful. They stressed that a code should be a practical and useful instrument developed by nurses for nurses, and that it should be formulated and presented in a practical way, just (...) as educational courses dealing specifically with codes of ethics require a practical approach to be effective. They emphasized that the development of a code should be an ongoing process, enabling nurses to provide input as they reflect on the ethical issues dealt with in the code and apply the code in their practice. Finally, they stressed the need for support at institutional level for the effective implementation of a code. (shrink)

It is argued here that bioethicists might inadvertently be promoting genetic determinism: the idea that genes alone determine human traits and behaviours. Discussions about genetic testing are used to exemplify how they might be doing so. Quite often bioethicists use clinical cases to support particular moral obligations or rights as if these cases were representative of the kind of information we can acquire about human diseases through genetic testing, when they are not. On other occasions, the clinical cases are presented (...) in simplistic ways that portray genetic testing as yielding information more accurate than it actually is. It is concluded that, because of the problematic implications that the ideology of genetic determinism might have for individuals’ wellbeing and for our public policies, bioethicists should be careful to present these issues in ways that do not promote questionable ideas about the causal role of genes in human diseases and behaviours. (shrink)

The argument from inductive risk has been embraced by many as a successful account of the role of values in science that challenges the value-free ideal. We argue that it is not obvious that the argument from inductive risk actually undermines the value-free ideal. This is because the inductive risk argument endorses an assumption held by proponents of the value-free ideal: that contextual values never play an appropriate role in determining evidence. We show that challenging the value-free ideal ultimately requires (...) rejecting this assumption. (shrink)

Este trabalho apresenta algumas considerações do pensador italiano Gianni Vattimo acerca da religião na idade contemporânea. O referido filósofo tem como base de suas reflexões a ideia de uma filosofia pós-moderna que se caracteriza pela desconstrução da metafísica da tradição moderna. Nesse sentido, o autor visualiza nas filosofias de Nietzsche e Heidegger a inauguração de uma nova orientação do pensamento ocidental, marcada por esse rompimento com as filosofias totalizantes e pela consideração do ser como resultado das circunstancias eventuais que compõem (...) a experiência existencial. A religião, por sua vez, não acompanhou tal movimento, mas conservou um pensamento marcado ainda pela estrutura da metafísica tradicional, por isso, não se encontra em condições de responder às atuais demandas deste mundo plural. O autor sinaliza para a necessidade da abdicação das estruturas dogmáticas e dos fundamentalismos da religião como meio para a abertura ao diálogo inter-religioso e intercultural. (shrink)

Philosophers of science, particularly those working on science and values, often talk about the need for science to be socially responsible. However, what this means is not clear. In this paper, we review the contributions of philosophers of science to the debate over socially responsible science and explore the dimensions that a fruitful account of socially responsible science should address. Our review shows that offering a comprehensive account is difficult. We contend that broad calls for socially responsible science that fail (...) to attend to relevant dimensions are not the solution, as they preclude meaningful changes to research institutions and practices. We conclude that narrower, more explicit accounts are more likely to lead to substantive transformation. (shrink)

In this paper, I submit that it is the controlled part of skilled action, that is, that part of an action that accounts for the exact, nuanced ways in which a skilled performer modifies, adjusts and guides her performance for which an adequate, philosophical theory of skill must account. I will argue that neither Jason Stanley nor Hubert Dreyfus have an adequate account of control. Further, and perhaps surprisingly, I will argue that both Stanley and Dreyfus relinquish an account of (...) control for precisely the same reason: each reduce control to a passive, mechanistic, automatic process, which then prevents them from producing a substantive account of how controlled processes can be characterized by seemingly intelligent features and integrated with personal-level states. I will end by introducing three different kinds of control, which are constitutive of skilled action: strategic control, selective, top–down, automatic attention, and motor control. It will become clear that Dreyfus cannot account for any of these three kinds of control while Stanley has difficulty tackling the two latter kinds. (shrink)

The lack of public support for climate change policies and refusals to vaccinate children are just two alarming illustrations of the impacts of dissent about scientific claims. Dissent can lead to confusion, false beliefs, and widespread public doubt about highly justified scientific evidence. Even more dangerously, it has begun to corrode the very authority of scientific consensus and knowledge. Deployed aggressively and to political ends, some dissent can intimidate scientists, stymie research, and lead both the public and policymakers to oppose (...) important public policies firmly rooted in science. -/- To criticize dissent is, however, a fraught exercise. Skepticism and fearless debate are key to the scientific process, making it both vital and incredibly difficult to characterize and identify dissent that is problematic in its approach and consequences. Indeed, as de Melo-Martín and Intemann show, the criteria commonly proposed as means of identifying inappropriate dissent are flawed and the strategies generally recommended to tackle such dissent are not only ineffective but could even make the situation worse. -/- The Fight Against Doubt proposes that progress on this front can best be achieved by enhancing the trustworthiness of the scientific community and by being more realistic about the limits of science when it comes to policymaking. It shows that a richer understanding of the context in which science operates is needed to disarm problematic dissent and those who deploy it. This, the authors argue, is the best way forward, rather than diagnosing the many instances of wrong-headed dissent. (shrink)

Although science is our most reliable producer of knowledge, it can also be used to create ignorance, unjustified doubt, and misinformation. In doing so, agnotological practices result not only in epistemic harms but also in social ones. A way to prevent or minimise such harms is to impede these ignorance-producing practices. In this paper, I explore various challenges to such a proposal. I first argue that reliably identifying agnotological practices in a way that permits the prevention of relevant harms is (...) more difficult than it might appear. I focus on an identifying criterion that many find apt for the task: bad faith motives. I then consider an objection—that reliable criteria are unnecessary to successfully address the concerns raised by agnotological strategies—and I show that it fails. I conclude by exploring other ways of conceptualising the problems attributed to agnotological practices. In particular, I challenge the focus on misinformation as the main problem of concern. (shrink)

While various definitions of moral distress have been proposed, some agreement exists that it results from illegitimate constraints in clinical practice affecting healthcare professionals’ moral agency. If we are to reduce moral distress, instruments measuring it should provide relevant information about such illegitimate constraints. Unfortunately, existing instruments fail to do so. We discuss here several shortcomings of major instruments in use: their inability to determine whether reports of moral distress involve an accurate assessment of the requisite clinical and logistical facts (...) in play, whether the distress in question is aptly characterized as moral, and whether the moral distress reported is an appropriate target of elimination. Such failures seriously limit the ability of empirical work on moral distress to foster appropriate change. (shrink)

When reflecting on the nature of skilled action, it is easy to fall into familiar dichotomies such that one construes the flexibility and intelligence of skill at the level of intentional states while characterizing the automatic motor processes that constitute motor skill execution as learned but fixed, invariant, bottom-up, brute-causal responses. In this essay, I will argue that this picture of skilled, automatic, motor processes is overly simplistic. Specifically, I will argue that an adequate account of the learned motor routines (...) that constitute embodied skills cannot be given in a purely bottom-up, brute-causal fashion. Rather, motor control is intelligent all the way down. To establish this, I will first review two recent accounts of skill, Stanley and Krakauer and Papineau, which characterize the automatic motor control responsible for the fine-grained movements constitutive of motor skill as brute, low-level phenomena. I will then isolate five key features that should apply to skilled motor control, if these accounts are correct. Together, the accounts posit that motor control is: ballistic, invariant, independent of general action trajectories, Insensitive to semantic content, and independent of personal-level intentions. In the final section of this paper, I will appeal to optimal control theory for empirical evidence to challenge the commitment to skilled action as qualified by the above features. (shrink)

It is not rare in philosophy and psychology to see theorists fall into dichotomous thinking about mental phenomena. On one side of the dichotomy there are processes that I will label “unintelligent.” These processes are thought to be unconscious, implicit, automatic, unintentional, involuntary, procedural, and non-cognitive. On the other side, there are “intelligent” processes that are conscious, explicit, controlled, intentional, voluntary, declarative, and cognitive. Often, if a process or behavior is characterized by one of the features from either of the (...) above lists, the process or behavior is classified as falling under the category to which the feature belongs. For example, if a process is implicit this is usually considered sufficient for classifying it as “unintelligent” and for assuming that the remaining features that fall under the “unintelligent” grouping will apply to it as well. Accordingly, if a process or behavior is automatic, philosophers often consider it to be unintelligent. It is my goal in this paper to challenge the conceptual slip from “automatic” to “unintelligent”. I will argue that there are a whole range of properties highlighted by the existing psychological literature that make automaticity a much more complex phenomenon than is usually appreciated. I will then go on to discuss two further important relationships between automatic processes and controlled processes that arise when we think about automatic processes in the context of skilled behavior. These interactions should add to our resistance to classifying automaticity as unintelligent or mindless. In Sect. 1, I present a few representative cases of philosophers classifying automatic processes and behaviors as mindless or unintelligent. In Sect. 2, I review trends in the psychology of automaticity in order highlight a complex set of features that are characteristic, though not definitive, of automatic processes and behaviors. In Sect. 3, I argue that at least some automatic processes are likely cognitively penetrable. In Sect. 4, I argue that the structure of skilled automatic processes is shaped diachronically by practice, training and learning. Taken together, these considerations should dislodge the temptation to equate “automatic” with “unintelligent”. (shrink)

Some health care organizations allow physicians to withhold cardiopulmonary resuscitation from a patient, despite patient or surrogate requests that it be provided, when they believe it will be more harmful than beneficial. Such cases usually involve patients with terminal diagnoses whose medical teams argue that aggressive treatments are medically inappropriate or likely to be harmful. Although there is state-to-state variability and a considerable judicial gray area about the conditions and mechanisms for refusals to perform CPR, medical teams typically follow a (...) set of clearly defined procedures for these decisions. The procedures are based on the principle of nonmaleficence and typically include consultation with hospital ethics committees, reflecting the guidelines of relevant professional associations. Ethical debates about when CPR can and should be limited tend to rely more on discussions of theory, principles, and case studies than systematic empirical study of the situations in which such limitations are applied. Sociologists of bioethics call for empirical study, arguing that what ethicists and health professionals believe they are doing when they draft policies or invoke principles does not always mirror what is happening on the ground. In this article, we begin the task of modeling the empirical analyses sociologists call for, focusing on a cohort at Massachusetts General Hospital. We inductively analyzed ethics committee notes and medical records of nineteen patients whose surrogates did not accept the decision to withhold CPR. (shrink)

When reflecting on the nature of skilled action, it is easy to fall into familiar dichotomies such that one construes the flexibility and intelligence of skill at the level of intentional states while characterizing the automatic motor processes that constitute motor skill execution as learned but fixed, invariant, bottom-up, brute-causal responses. In this essay, I will argue that this picture of skilled, automatic, motor processes is overly simplistic. Specifically, I will argue that an adequate account of the learned motor routines (...) that constitute embodied skills cannot be given in a purely bottom-up, brute-causal fashion. Rather, motor control is intelligent all the way down. To establish this, I will first review two recent accounts of skill, Stanley and Krakauer (Front Hum Neurosci, 2013. doi:10.3389/fnhum.2013.0050) and Papineau (R Inst Philos Suppl 73:175–196, 2013), which characterize the automatic motor control responsible for the fine-grained movements constitutive of motor skill as brute, low-level phenomena. I will then isolate five key features that should apply to skilled motor control, if these accounts are correct. Together, the accounts posit that motor control is: (1) ballistic, (2) invariant, (3) independent of general action trajectories, (4) Insensitive to semantic content, and (5) independent of personal-level intentions. In the final section of this paper, I will appeal to optimal control theory for empirical evidence to challenge the commitment to skilled action as qualified by the above features. (shrink)

Biological theory demands a clear organism concept, but at present biologists cannot agree on one. They know that counting particular units, and not counting others, allows them to generate explanatory and predictive descriptions of evolutionary processes. Yet they lack a unified theory telling them which units to count. In this paper, I offer a novel account of biological individuality, which reconciles conflicting definitions of ‘organism’ by interpreting them as describing alternative realisers of a common functional role, and then defines individual (...) organisms as essentially possessing some mechanisms that play this role. (shrink)

Darwin’s classic ‘Origin of Species’ (Darwin 1859) described forces of selection acting upon individuals, but there remains a great deal of controversy about what exactly the status and definition of a biological individual is. Recently some authors have argued that the individual is dispensable – that an inability to pin it down is not problematic because little rests on it anyway. The aim of this paper is to show that there is a real problem of biological individuality, and an urgent (...) need to arbitrate over the current plethora of solutions to it. (shrink)

The aim of this paper is to show that critics of biological explanations of human nature may be granting too much to those who propose such explanations when they argue that the truth of genetic determinism implies an end to critical evaluation and reform of our social institutions. This is the case because when we argue that biological determinism exempts us from social critique we are erroneously presupposing that our social values, practices, and institutions have nothing to do with what (...) makes biological explanations troublesome. My argument is that what constitutes a problem for those who are concerned with social justice is not the fact that particular behaviours may be genetically determined, but the fact that our value system and social institutions create the conditions that make such behaviours problematic. Thus, I will argue that even if genetic determinism were correct, the requirement of assessing and transforming our social practices and institutions would be far from superfluous. Biology is rarely destiny for human beings and the institutions they create. (shrink)

This article presents a critical bibliographic review of the central characteristics of Hume's Theory of Passions and Emotions, which conceived the philosophy of human nature as an analytical and experimental science. This view is contrary to the ancient and medieval ideas that passions were movements of the lower parts of the soul. For Hume, passions in general are among the perceptions of the mind, although they also serve as motivations to act and even to reason. The apparent dichotomy that existed (...) between passions and reason was abandoned and reason was treated as a calm passion. Hence, Hume dethroned reason from its sovereign position in knowledge. For him, passions are neither subordinate nor independent of reason; it is the reason that is subordinate to passions. (shrink)

This study empirically tests a sequential mediation model that links ethical leadership with employees’ unethical behaviour. The corruption index for countries is used as the moderator, because it represents both the instrumental ethical climate and the employee displacement of responsibility embedded in society’s ethical standards. A total of 175 participants comprising 41 teams (134 dyads) across 13 countries participated in a dyadic two-wave survey. The findings show that ethical leadership has an indirect influence on the avoidance of unethical behaviour by (...) reducing the instrumental ethical climate and by negating the displacement of individuals’ responsibility. In addition, the results also show that this process is not sensitive to the countries’ corruption levels. Such findings suggest that organizations are less prone to adjust their ethical standards to the environment than is usually expected. Accordingly, ethical leaders of MNCs may be instrumental in counteracting any corruptive pressure in the social environment, and likewise, non-ethical leaders may be a contributing factor to fostering corrupt organizations in a society that otherwise values ethical principles in business. (shrink)